Posttraumatic Stress Disorder and Physical Illness: Results from Clinical and Epidemiological Studies


Below are some excerpts from this study on PTSD in Vietnam Veterans and the associations to clinically found other disorders, whom to contact to get a copy of the study, and so forth.


Now, as I understand it you have to get a copy of this to your doctor and have him write up the relationship of your PTSD to the clinical medical disorders but this study can be used in citing the connection.  Some have informed me this was found by the VA to be acceptable.


The studies on my claim that I submitted which were our “governments own studies” failed to meet this level of VA acceptability.  This is certainly confusing on my part since the government’s own studies I submitted had dioxin linear responses found and other government studies had p-values stated to the dioxin levels and Odds Ratio to the disorder clearly stated as to levels of association to the dioxin, TCDD and also levels of difference between Vietnam Veterans and Non Vietnam Veterans.  Maybe it is just the Atlanta VA or maybe it is just the Atlanta VA and I.  Therefore, as a “root cause failure analysis engineer,” I am at a loss here. 


I guess I should not be and should not expect anything less from the Atlanta VA and the VA as a federal agency.


In fact, I studied this subject and our subject for six months to make sure I personally deserved “any compensations” in my own mind before I submitted the first paperwork to the VA in 2002.  Then with my integrity in hand got my teeth kicked in by this agency and our government because of shear power and because the folks that are denying this do not have a clue what they are even looking at.


Anyway the below study and contact info should help some of you.


The sad part here is that everything this doctor is saying was found in the Ranch Hand studies; the Korean Studies; the Australian Studies; the Seveso, Italy studies; the IARC, our own nation’s EPA, etc and not to PTSD but to the dioxin, TCDD.


I would add the excerpt below shows M –Immunoglobulin levels were “clinical higher.”  I am not sure what that means or infers.  Clinically higher could mean within the established range.  That range depending on the lab is about 700 –1600.  I am assuming that it means that the patients were consistently higher in range such as me, as I run about 1555.  What is also factual as being found is not only disturbance in the well being of IgG1 – IgG4 but also an increase in IgE and IgA and NK cells.


My IgA runs 3 times what is considered max and my IgE is about 2.5 times what is considered max and my IgG1 –IgG4 deltas to each other are skewed but according to the Atlanta VA has nothing to do with this same thing shown in study after study associated to the dioxin, TCDD.   


Dysregulation of B and T cells along with increases in Interlukin 04 and Interlukin 10; and guess what?  -- A decrease in Interferon gamma.  Any of you Hep C Veterans ever heard of Interferon gamma?


What does all that mean? 


It means the bodies defenses against cancer causing viruses is weak such as Epstein Barr Virus, or autoimmune diseases or allergies develop with no hereditary markers or rationale for why you are the only one in your family, or extreme sensitivity to other chemical exposures, or constant infections, or anything associated to the immune system including screwing up the immune systems type 1 and type 2 responses (when it should have a type 1 response it now has a type 2 response or visa versa or both occur at the same time); it is now totally hosed.


As suggested below you have constant inflammatory conditions on-going in your body and unlike the VA’s determination this condition is somehow, “self-righting” it is continuous and constant - wavering only in acuteness and degrading the body’s systems and organs.  This is known as systemic damages.


Anyway, here is the study excerpts.


Hope it helps some of you to get your medical issues associated, as it should be. 


Remember your medical issues are just as important to fight for as your PTSD issues, if not more so.




Posttraumatic Stress Disorder and Physical Illness: Results from Clinical and Epidemiological Studies




Division of Health and Science Policy, The New York Academy of Medicine, New York, New York 10029-5293, USA

Research Service, Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey, USA


Address for correspondence: Joseph Boscarino, Division of Health and Science Policy, Room 552, The New York Academy of Medicine, 1216 Fifth Avenue, New York, NY 10029-5293.  Voice: 212-419-3551; fax: 212-822-7369.  jboscarino{at}


Research indicates that exposure to traumatic stressors and psychological trauma is widespread.  The association of such exposures with posttraumatic stress disorder (PTSD) and other mental health conditions is well known.  However, epidemiological research increasingly suggests that exposure to these events is related to increased health care utilization, adverse health outcomes, the onset of specific diseases, and premature death.  To date, studies have linked traumatic stress exposures and PTSD to such conditions as cardiovascular disease, diabetes, gastrointestinal disease, fibromyalgia, chronic fatigue syndrome, musculoskeletal disorders, and other diseases. Evidence linking cardiovascular disease and exposure to psychological trauma is particularly strong and has been found consistently across different populations and stressor events.  In addition, clinical studies have suggested the biological pathways through which stressor-induced diseases may be pathologically expressed.  In particular, recent studies have implicated the hypothalamic-pituitary-adrenal (HPA) and the sympathetic-adrenal-medullary (SAM) stress axes as key in this pathogenic process, although genetic and behavioral/psychological risk factors cannot be ruled out.  Recent findings, indicating that victims of PTSD have higher circulating T-cell lymphocytes and lower cortisol levels, are intriguing and suggest that chronic sufferers of PTSD may be at risk for autoimmune diseases. To test this hypothesis, we assessed the association between chronic PTSD in a national sample of 2,490 Vietnam veterans and the prevalence of common autoimmune diseases, including rheumatoid arthritis, psoriasis, insulin-dependent diabetes, and thyroid disease.  Our analyses suggest that chronic PTSD, particularly comorbid PTSD or complex PTSD, is associated with all of these conditions.  In addition, veterans with comorbid PTSD were more likely to have clinically higher T-cell counts; hyper reactive immune responses on standardized delayed cutaneous hypersensitivity tests, clinically higher immunoglobulin-M levels, and clinically lower dehydroepiandrosterone levels.  The latter clinical evidence confirms the presence of biological markers consistent with a broad range of inflammatory disorders, including both cardiovascular and autoimmune diseases.

Key Words: posttraumatic stress disorder (PTSD) • comorbid/complex PTSD • coronary heart disease (CHD) • autoimmune disease • hypothalamic-pituitary-adrenal (HPA) axis

Some more links to this study and the PTSD caused medical issues.