Korean Immunotoxicological effects found

 

 

In an additional study done by the Koreans on the immune system states: 

 

"Overall this study suggests that military service in Vietnam and/or Agent Orange exposure disturbs immune-homeostasis resulting in in dysregulation of B and T cells."

 

(B Cells are cells that are associated with bone marrow and T Cells are cells associated with the thymus.)

 

As I have indicated in this issue the compensation should be on any medical issues that is a result of this "damaging process."  The process is the causation; not the cherry picked end item medical issue that can be different from individual to individual for many medical reasons and exposure reasons.  And this includes many forms of autoimmune disorders that are just as cruel as a cancer.  Even more so in some cases.

 

Based on the results of two Governmental studies peripheral nerve disease is the most prevalent disease, followed by lung cancer, Buerger's disease, larynx cancer, non-hodgkin's, lymphoma, and chloracne associated with Agent Orange.

 

Symptoms of Buerger's disease

Now of course peripheral nerve disease cannot possibly be the most prevalent disease connected with Agent Orange in two separate studies.  Our Secretary of the VA has commanded it so from Mount Olive along with the government contracted NAS/IOM.  In addition, there is no way these men have this disorder at this late date because our Secretary of the VA has declared they should have already had this disorder one year after leaving Vietnam and cured within two years.  These Korean doctors who are obviously incompetent  need to get with our government contracted NAS/IOM for the cure.  Or maybe ask our congress for the cure since they swallow all this lying medical stuff put out by the VA and the NAS/IOM.

 

This would also mean that all those VA legal pinhead counselors are also lying through their teeth at the BVA.

 

Yes, sarcastic but also criminal what the VA and the NAS/IOM are doing as well as the congress of the United States to the Nations Veterans.

 

As I suggested a few years ago not all of this nerve damage is from diabetes as the VA would have you believe.

 

The list of *probable associated disorders most prevalent was hypertension followed by diabetes, seborreheic dermatitis, central nervous system diseases, liver diseases, multifocal neuropathy, cancer, hyperlipidemia, cerebrovascular disease, ischemic heart disease, and other skin diseases such as chronic urticaria, psoriasis vulgaris.

 

*Probable in this case means probable to AO.  They found these associated to service in Vietnam regardless of what caused it.

 

You cannot have a p-value of comparison of 0.0002 with no one in the opposing cohort group having the the issues and then say it is not related to service in Vietnam.  Unless you are the government contracted NAS/IOM or the government appointed Secretary of the VA.

 

Immune-homeostasis from above in simple terms means your immune system becomes ineffective or it is over reactive.  In some cases it can be both.  Simply put; cells no longer call for themselves when they are needed; or they call for themselves when they are not needed; in some cases no amount of production will satisfy the requirement; and/or they no longer recognize antigens as antigens and attack the body's own self.

 

I guess another way to put would be a balance of power shift in antibodies.  This shift can point out many immune system disorders as well as cancers or tumors.  Including an autoimmune disorder or long-term chronic liver damage.

 

Going through several phases of cell maturation then you may have a cancerous condition.  But as I told the Representative for the Veterans Affairs Committee if we all had cancer this would be easy to discern.  This is of course is not the real facts.

 

They also found that qualitative characteristics of red blood cells is altered, T-cell subset activity is altered, and distribution of IgG subclasses is altered.

 

Whether this find of altered qualitative characteristics of red blood cells would cause the A1C testing anomaly found in the Ranch Hand study.   I can only guess it would have an impact.

 

I think Dr. Albanese tried to make the red blood cell issues known in the 2000 oversight committee and not one congressman listened.

 

I had submitted to the VA that there had to be a connection with the antibodies just from reviewing what my studies had found along with Dr. Norman Latov's articles on these antibody subsets and what symptoms and diseases are associated.  The man is the "worlds foremost expert" on this and no one is working with him.  Especially the VA and the NAS/IOM.  I will never under stand that.

 

The only issue is that Columbia University with its tie into the American Legion who spent millions of dollars on research and their researchers are somewhat pro-veteran.  As you may recall one group actually stated the way you do research is working with victims, establish the data, and form conclusions.  Not by modifying or changing the data as they suggested the government has been doing all along.

 

Also noted in the Korean study was that in their Veterans the average was at least 1.5 chronic diseases per person.  As I have stated many times you might have symptoms from two different ICD codes yet none of match the 100 year old definition of some doctors desk reference manual.  Which is why doctors say I do not know what is going on or why!!!!!!!!!!!!!

 

It seems they found an issue with a lower IgG1 antibody and an issue with IgE antibodies.  In looking at the test data besides the significant IgG1 decrease and the more than double IgE antibodies;  it looks like the trend is IgG2 = lower; IgG3 = lower; and IgG4 = lower.  IgG2-4 lowering did not reach what they called significant but it is a trend. I would think the delta between the Veterans and the control on IgG2 should have been marked as "abnormal or significant."

 

If you do the worst and best case tolerance analysis that they assigned on both you have a 64% shift for IgG1 and a 63.5% shift for IgG2.  Why they did not include IgG2 as being significant I do not know.  Damn sure close enough for government work for me. Ha Ha

 

IgG3 and IgG4 were a few points off but never the less the trend is down in both.

 

Now with my lack of education I had not put this together but I think this study now clearly shows that within each of the classified antibodies;  under subsets, you can also have a balance of power shift.  This will also point out many issues as it relates to the matrix of problems caused.

 

Here is the other thing that burns my rear-end.  I thought this was a new discovery and apparently this has been found to a linear dose response in two other studies.  One from the Seveso, Italy dioxin exposure and one from a German study that reported a linear effect from exposures to TCDD; especially for IgG1.

 

If you read my comparison of the Rockpile and Seveso, Italy exposures at

 

http://www.2ndbattalion94thartillery.com/Chas/NewItems.htm

 

As far as exposures go; Seveso, Italy was a pimple in comparison and that was for only dioxin exposures.

 

As I have said many times some politicians,  federal officials, and federal employed scientists should be in prison!

 


Technical

 

The finding of a decreased level of one of the IgG subclasses can never provide a definite diagnosis, but should  be considered as an indication of a disturbance of the immune system, requiring further diagnostic investigation.


It appears that patients with IgG1 and/or IgG3 deficiency are more likely to have difficulty with chronic and recurrent infections of the lower respiratory tract.


Patients with IgG2 and/or IgG4 deficiency are more likely to have
sinusitis and otitisThis has also been reported in other civilian dioxin exposures as well. 

 

Deficiencies and complete deficiency/absence of individual IgG subclasses may have several consequences:

 

IgG1: IgG1 deficiencies often result in a decreased level of total IgG (hypogammaglobulinemia). A deficiency of this quantitatively most important subclass is often associated with recurrent infections and might occur in combination with (individual) deficiencies of other subclasses, e.g. IgG3 .


Reported are IgG1 subclass deficiencies in patients with chronic fatigue syndrome, whereas all other immunoglobulin isotypes were normal.


IgG1 deficiency is often associated with
Common Variable Immunodeficiency.

 

IgG2: An IgG2 deficiency is often associated with otitis media acuta and sinusitis, association with ataxia telangietasia (muscle coordination and compromised immune system) and with System Lupus Erythematosus (SLE) has also been reported.


In about half of all IgG subclass deficiencies the IgG2 concentrations are decreased. An isolated IgG2 deficiency is associated with decreased responses to infections with encapsulated bacteria and after immunisation with polysaccharide antigens .
These patients show recurrent respiratory tract infections with pneumococci and/or Haemophilus influenza type B . Low concentrations of IgG2 often occur in association with a deficiency in IgG4 and IgA.

 

IgG3: Along with IgG1, the IgG3 subclass is most frequently present in the antibody response to protein antigens. IgG3 deficiency has been associated with a history of recurrent infectious, leading to chronic lung disease. Decreased IgG3 levels are frequently associated with IgG1 deficiency.

 

In autoimmune diseases the levels of IgG subclasses do mostly not differ from those in healthy individuals, but specific auto antibodies show variable subclass restrictions: frequently, auto antibodies are of the IgG1 and IgG3 subclasses.


Human rheumatoid factors (RF) are defined as IgG, IgA or IgM antibodies against the Fc fragment of immunoglobulin. In most cases, RF have been found to bind to the Fc fragments of IgG. As for their subclass specificity, most RF have been shown to react with IgG1, followed by IgG2 and IgG4. Binding of RF to IgG3 is rare.

 

Abnormal IgG1: IgG2 ratios have been reported in patients suffering from connective tissue diseases. In case of a selective polyclonal increase of IgG1, one should be alert for the possibility of Sjögren's syndrome. It has been suggested that this immunoglobulin abnormality is the product of a restricted oligoclonal B cell response and may thus be the consequence of a benign B cell lymphoma .

 

Auto antibodies to neutrophil cytoplasmic antigens (ANCA) are predominantly of the IgG1 and IgG4 subclass . Auto antibodies of the IgG3 subclass almost exclusively occur in patients with renal involvement.



Many of you have constant throat infections and such with constant drainage at the back of throat and this could be why among many other more sinister issues.

 


 

The Korean doctors also covered the following *cytokine concentrations:

 

*Cytokines are a unique family of growth factors. Secreted primarily from leukocytes, cytokines stimulate both the humoral and cellular immune responses, as well as the activation of phagocytic cells. Cytokines that are secreted from lymphocytes are termed lymphokines, whereas those secreted by monocytes or macrophages are termed monokines. A large family of cytokines are produced by various cells of the body. Many of the lymphokines are also known as interleukins (ILs), since they are not only secreted by leukocytes but also able to affect the cellular responses of leukocytes. Specifically, interleukins are growth factors targeted to cells of hematopoietic origin.

 

IFN-g was elevated

 

TNF-a was elevated

 

IL-4 was elevated

 

IL-10 was elevated

 

IL-4:INF-g ratio was elevated

 

IFN-gamma - I could not find much on that I could understand.  It seems to play a part in IgA, intestinal epithelial cell issues, and has been associated with Downs.  I will continue to look for something I can understand.

 

TNF-alpha -

Tumor Necrosis Factor

TNF-alpha (also called cachectin), like IL-1 is a major immune response-- modifying cytokine produced primarily by activated macrophages. Like IL-1, TNF-a induces the expression of other autocrine growth factors, increases cellular responsiveness to growth factors and induces signaling pathways that lead to proliferation. TNF-a acts synergistically with EGF and PDGF on some cell types. Like other growth factors, TNF-a induces expression of a number of nuclear proto-oncogenes as well as of several interleukins.

 

IL-4 = B cell proliferation, eosinophil and mast cell growth and function, IgE and class II MHC expression on B cells, inhibition of monokine production.

 

IL -10 = inhibits cytokine production, promotes B cell proliferation and antibody production, suppresses cellular immunity, mast cell growth.

 

Epidermal Growth Factor (EGF)

EGF, like all growth factors, binds to specific high-affinity, low-capacity receptors on the surface of responsive cells. Intrinsic to the EGF receptor is tyrosine kinase activity, which is activated in response to EGF binding. The kinase domain of the EGF receptor phosphorylates the EGF receptor itself (autophosphorylation) as well as other proteins, in signal transduction cascades, that associate with the receptor following activation. Experimental evidence has shown that the Neu proto-oncogene is a homologue of the EGF receptor.

 

EGF has proliferative effects on cells of both mesodermal and ectodermal origin, particularly keratinocytes and fibroblasts. EGF exhibits negative growth effects on certain carcinomas as well as hair follicle cells. Growth-related responses to EGF include the induction of nuclear proto-oncogene expression, such as Fos, Jun and Myc. EGF also has the effect of decreasing gastric acid secretion.


 

After all of this headache stuff the bottom line is they found some issues and the sad part about is it seems to have been found and confirmed now on at least three studies.

 

Now the Ranch Hand did find some increase in CD16 positive and CD56 positive natural killer cells.  They also had some discussion on sedimentation rate and lymphocytes.  Then the scientist who was presenting this chapter on the immune system alluded to the fact that substantial changes were being suggested, “to de-emphasize the chapter” and its findings.

 

Now that ought to give every Veteran a warm and fuzzy feeling.

 

Including that before that they had said with the IgA and some of the other issues that were found it was representative of a chronic dose inflammatory response.

 

In fact with the findings above that pretty much says that dioxin can be a tumor promoter regardless if it created the tumor or not.  Just as the EPA has stated and it was actually tossed about in the Ranch Hand transcripts and then debunked; once again.

 

This growth factor and immune system issues was also found by the EPA.

 

EPA dioxin expert states:

 

“At levels below that where you see wasting, you can see effects on the lymphoid tissues and you actually have loss of the thymus and spleen and at slightly lower levels, and in the adult male you can have atrophy of the testis.  Effects on the liver--there are some differences in different species but, in general, you see enlargement of the liver, you see accumulation of fat in the liver.

 

“In some tissue, you have hyperplasia, which is a proliferation of cells.  The tissue actually gets bigger from having more cells, and this occurs in the lining of the gastro-intestinal tract, it occurs in the lining of the urinary tract, and it occurs in the bile duct, which comes from the liver.

 

“In other kinds of cells, instead of getting hyperplasia, which is an inappropriate proliferation of cells, you get squamous metaplasia, which is an inappropriate differentiation of cells.”

 

Now I know what you are thinking after reading that bit from the EPA.  Why is it civilians can get all of this and not the Veterans of the Nation; especially with regard to the liver bile duct and fat in the liver. 

 

I do not have an answer but you might contact the Congress, VA secretary, and the NAS/IOM and ask them why it is that military uniforms have this strange effect on dioxin.  You might ask them why it is the Ranch Hand found this increase in GGT enzymes and then debunked it also.

 

One thing in reading the Korean report, which I will contact them next week, is I did not see a complete test set up for all antibodies.  Maybe they did and did not put that in the abstract or the write up.  It seems they honed in on only IgG and IgE from the all the skin issues they found in the first study, I think.

 

Regardless of that, I think the study found enough that should be included in compensations and health treatment as "service connected."

 

I still think Alan hit the nail on the head on these issues and this all stems from the damaged to the liver and/or endocrine system and its hormones and enzymes.  Especially, since the Koreans found cell function issues in "plating efficiency" and "mitogen response."

 

This study just adds one more study that adds credence to my novice conclusions of associated disorders:

 

Non-Hodgkin’s lymphoma, chloracne and other skin disorders, lip cancer, bone cancer, soft tissue sarcoma, birth defects (physical and mental), skin cancer, porphyria cutanea tarda family of disorders and other liver disorders (such as biliary disorders), Hodgkin’s disease, hematopoietic diseases, multiple myeloma, neurological defects (such as neuropathy (any form), and cognitive disorders and deficits), autoimmune diseases and disorders (defined and undefined medical codes), leukemia, lung cancer and forms of obstructive airway diseases, kidney cancer, malignant melanoma, pancreatic cancer, stomach cancer, colon cancer, nasal/pharyngeal/esophageal cancers, prostate cancer, testicular cancer, liver cancer, brain cancer, neuropsychological effects, gastrointestinal diseases, amyloidosis (primary, secondary, or toxic chemical tertiary), macroglobulinemia (in any form), forms of  osteoporoses and/or bone loss due to vascular necrosis, spondylosis, radiculopathy (including herniation of the nucleolus pulposus), brain atrophy, brain infarction, ischemic heart disease, hypertension, vasculopathy, vascular diseases, valvular heart disease, MS, and Parkinson’s. 

 

 

Best to all,

 

Kelley 

 

 

SP5Kelley2nd94th@aol.com